Medg 545 – journal club current topics in medical genetics research 2013W medg 545

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MEDG 545 is a 3-credit, two-termelectivecourse with the format of a Journal Club. The purpose of this course is to assist students to learn to critically evaluate scientific literature and to hone their general presentation skills. Unlike other courses, participation in a Journal Club includes post-doctoral fellows (post-docs), faculty and staff. Students registering for MEDG 545 have their choice of several Journal Clubs with different themes and at different locations. Students taking the course for credit are expected to continue to attend a Journal Club throughout their time as a graduate student. Non-Medical Genetics (MEDG) students are welcome to take MEDG 545.If space is limited, priority will be given to the students in the Medical Genetics Graduate Program.

First year Medical Genetics (MEDG) students should obtain permission via email from the coordinator of their selected journal club and forward that email to Cheryl

Non-MEDG students must submit a “Permission to Register” form to Cheryl.

1. Molecular Mechanisms of Disease

Faculty: Drs. Blair Leavitt, Liz Conibear, Dan Goldowitz, Stefan Taubert

Location: Centre for Molecular Medicine and Therapeutics (CMMT), Child & Family Research Institute, Room 2027,950 W. 28th Avenue, Vancouver, BC

Information session:September 12, 2013

First presentation: September 26, 2013

Following first presentation: Every Second Thursday

Time: 4:00-5:00 PM

Description: This Journal Club discusses important recent literature as it pertains to our understanding of human disease mechanisms. We will focus in particular on altered function or mis-regulation of proteins involved in neurodegenerative diseases, lipid diseases, chromatin-remodeling syndromes and cancer.

This is an interactive Journal Club with one long and one short presentation per session. Students participating in this Journal Club for MEDG 545 credit are required to present at least once in the long and short format, to actively participate in the discussions, and to attend at least 90% of all sessions. All presenters are also required to discuss their choice of paper with one of the mentoring faculty at least one week before the presentation. The registration cap for students taking this journal club for credit is 13 students.

Journal Club Coordinator is Dr. Blair Leavitt: For General information, contact Angela Gurney:
2. Genetic Variation & Human Disease

: Dr. Jan Friedman

Location: Children’s & Women’s Hospital (C&W),Room C331,4500 Oak Street, Vancouver, BC

When: Every other Monday

Starting:September 16, 2013

Time:3:00 – 4:00PM
Description: This journal club discusses important recent literature as it pertains to the understanding of genetic variation and human disease. In particular, it focuses on the following:

  • From populations to individuals, current technologies of identification of human genetic variation including next generation sequencing and microarrays.

  • Discussion on sequence architecture that leads to genetic variation and disease.

  • Analysis of studies that determine the population risk and incidence of human genetic disease (e.g. genetic epidemiology and population genetics).

This is an interactive Journal Club. Students participating in this Journal Club for MEDG 545 credit are required to present at least once, to actively participate in the discussions, and to attend at least 90% of all sessions.

Journal Club Coordinatoris Dr. Jan Friedman: For general information, contact Isabel Filges:

3.Chromatin Club

Faculty: Drs. Matt Lorincz, Louis Lefebvre, Carolyn Brown& Molecular Epigenetics Group members

Location: Life Sciences Centre (LSC),Room 1416,2350 Health Sciences Mall, UBC Campus

When: Every other Tuesday

Introductory& sign-in session:September 3, 2013

Starting:September 17, 2013

Time:4:00 – 5:00 PM

Description: This Journal Club meets bi-weekly, alternating weeks with research presentations (wing talks) from the Molecular Epigenetics Group and a monthly Epigenetics Seminar Series. Articles related to all aspects of chromatin structure and gene regulation are presented, with the article (from a recent primary research article) to be emailed to the group at least five days before the meeting. Students taking the class for credit must present once each term; and are graded on both their presentation and their participation at other presentations (for which they are expected to read the paper and any necessary background). Course supervisor permission is required to take the course for credit, and a maximum of 5 students will be permitted to register each term, with preference given to students whose supervisors regularly attend this journal club. Upon taking the course for credit, students are expected to attend and participate for the rest of their graduate studies.

Journal Club Coordinator is Dr. Louis Lefebvre:


Faculty: Drs. Kelly McNagny and Colby Zaph

Location: Biomedical Research Centre (BRC), Seminar Room, 2222 Health Sciences Mall, UBC Campus

Information sessionSeptember 20th

First presentationSeptember 27th

Following first session: Every Friday

Time4:00-5:00 PM

Description: High-profile thematic papers are presented by students, postdocs or faculty members who chair the discussion.  Paper presentation sessions will be supplemented with cutting-edge seminars from external speakers who are leaders in the field.  Presentations will cover a range of topics including stem cells and tissue regeneration and inflammatory mechanisms leading to tissue damage and fibrosis.  Students seeking credit are expected to chair one discussion per term and participate in others by reading each assigned paper, attending journal club, and asking relevant questions or contributing comments.

Journal Club Coordinators are: Drs. Kelly McNagny ( and Colby Zaph (

5. DevElopmental Origins of HeALth and Disease

Faculty: Dr. Wendy Robinson

Location:Child & Family Research Institute (CFRI), Room 2108, 950 W. 28th Avenue, Vancouver

First Session: SEPTEMBER 10, 2013

Following first session: Every Tuesday
Time: 12:00 – 1:00 PM(bring your tea, coffee, lunch)

This journal club discusses important recent literature as it pertains to the understanding of gene-environment interactions, epigenetics, and early influences on long-term health. In particular, it focuses on the following:

  • Environmental factors (stress, nutrition, drug treatments etc.) and their effect on the epigenome

  • Pre- and perinatal health and health outcomes.

  • Developmental biology as relates to abnormal placental and/or fetal development.

This is an interactive Journal Club. Everyone should have looked through the discussion paper ahead of time. PowerPoint is not allowed. One paper will typically be presented each session.

Journal Club Coordinator is Dr. Wendy Robinson:

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