Attorney Docket No. Ntma: 2009




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Attorney Docket No. NTMA:2009


    CLAIMS

  1. A method for treating one or more cancers in a patient comprising a combination of one or more treatment modalities selected from the group consisting of:

administering a radiation therapy;

administering a chemotherapy;

performing a surgical intervention;

injecting a sterile polymannan extract formulation two to three times in a week, wherein the sterile injectable polymannan extract formulation comprises a specified quantity of very fine polymannan extract dissolved in deionized water; and one or more pharmaceutical preservatives;

administering an alkaline diet by itself or as a supplement along with a regular diet to create an alkaline milieu, maintain an alkaline milieu or both, wherein the alkaline diet comprises: a solution of sodium bicarbonate, one or more alkaline ash forming foods selected from the group consisting of alfalfa sprouts, artichokes, broccoli, cantaloupe, celeriac, cranberries, dates, flaxseed, huckleberries, lemons, almonds, apples (apple cider) apricots, bananas, beets, blackberries, blueberries, brussel sprouts, burdock cabbage, carob carrots, cauliflower, celery, chard, cherries, chives, coconut, cucumbers, currants, dandelion greens, dill, dock, endive, figs (dried), garlic, grapefruit, green beans, guava, irish moss, kelp, kohlrabi leeks, lettuce, lima beans, limes, loganberries, loquats, molasses, nectarines, oranges, pears, radishes, rutabagas, squash, vegetable oils, mango, melons, millet mint, mulberries, muskmelon, mustard greens, okra, olives, olive oil, onions, papaya, parsley, parsnips, peaches, persimmons, pineapple, plums, pumpkin, raisins, raspberries, rhubarb, romaine, sea grass, sorrell, soybeans, spinach, strawberries, swisschard, tangerines, turnips, water chestnuts, watercress, and watermelon, and one or more optional flavoring agents, coloring agents, sweeteners, and other organoleptic compounds;

administering a therapeutically effective amount of a pharmaceutical composition orally or parenterally, wherein the composition comprises: a specified quantity of dichloroacetate (DCA) in a solid or liquid dosage form, a specified quantity of alpha lipoic acid (ALA) in a solid or liquid dosage form, and one or more optional pharmaceutically acceptable excipients selected from the group consisting of preservatives, bulking agents, anti adherents, lubricants, sweeteners, and other organoleptic agents; and

administering a nutritional composition comprising:


Vitamin C (Ascorbic acid, magnesium

ascorbate, calcium ascorbate, and palmitic ascorbate)



    700 mg

    L-Lysine

    1,000 mg

    L-Proline

    750 mg

    L-Arginine

    500 mg

    N-Acetyl Cysteine

    200 mg

Green tea Extract

Total polyphenols

Catechins

EGCG


Caffeine

    1000 mg

    80%


    60%

    35%


    1%

Minerals

Selenium


Copper

Manganese



    30 mcg


    2 mg

    1 mg

.


  1. The method of claim 1, wherein the one or more cancers are selected from the group consisting of leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer.

  2. The method of claim 1, wherein the polymannan extract is derived from an Aloe species selected from the group consisting of Aloe vera, Aloe arborescens, Aloe aristata, Aloe dichotoma, Aloe nyeriensis, Aloe variegate, Aloe barbadensis, and Aloe wildii.

  3. The method of claim 1, wherein the polymannan extract comprises aloe polysaccharides, wherein the aloe polysaccharides comprise one or more small chain, medium chain, large chain, very-large chain polysaccharides, or any combinations thereof.

  4. The method of claim 1, wherein the polymannan causes a 75-80% increase in one or more natural killer (NK) cells.

  5. The method of claim 1, wherein the polymannan extract increases a level of a caspase 3 protein in the blood, wherein an increased level in caspase 3 is directly related to an increased level of apoptosis of the one or more cancer cells.

  6. The method of claim 1, wherein the administration of the alkaline diet comprises an optional step of injecting a 5% sterile solution of sodium bicarbonate to help create or maintain the alkaline milieu in the patient.

  7. The method of claim 1, wherein the pharmaceutical composition prevents or slows a growth and a proliferation of one or more cancer cells, induces an apopotosis of the one or more cancer cells or both.

  8. The method of claim 1, wherein the nutritional composition prevents angiogenesis, a growth, a proliferation or both of the one or more cancer cells.

  9. The method of claim 1, wherein the nutritional composition is administered once or multiple times in a day before or after meals.

  10. An alkaline diet for the treatment of one or more malignancies selected from the group consisting of leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, and for the treatment of one or more immune disorders comprising:

a solution of sodium bicarbonate;

one or more alkaline ash forming foods selected from the group consisting of alfalfa sprouts, artichokes, broccoli, cantaloupe, celeriac, cranberries, dates, flaxseed, huckleberries, lemons, almonds, apples (apple cider) apricots, bananas, beets, blackberries, blueberries, brussel sprouts, burdock cabbage, carob carrots, cauliflower, celery, chard, cherries, chives, coconut, cucumbers, currants, dandelion greens, dill, dock, endive, figs (dried), garlic, grapefruit, green beans, guava, irish moss, kelp, kohlrabi leeks, lettuce, lima beans, limes, loganberries, loquats, molasses, nectarines, oranges, pears, radishes, rutabagas, squash, vegetable oils, mango, melons, millet mint, mulberries, muskmelon, mustard greens, okra, olives, olive oil, onions, papaya, parsley, parsnips, peaches, persimmons, pineapple, plums, pumpkin, raisins, raspberries, rhubarb, romaine, sea grass, sorrell, soybeans, spinach, strawberries, swisschard, tangerines, turnips, water chestnuts, watercress, and watermelon; and

one or more optional flavoring agents, coloring agents, sweeteners, and other organoleptic compounds.


  1. The composition of claim 11, wherein the diet is administered by itself or as a supplement along with a regular diet comprising a balanced proportion of nutritional elements selected from the group consisting of proteins, fats, carbohydrates, fiber, vitamins, and minerals.

  2. The composition of claim 11, wherein a patient or a subject on the alkaline diet is required to have a normal to above normal fluid intake, wherein the fluids comprise water, fruit juices, nutritional drinks, milk and combinations thereof.

  3. A method of treating a patient suffering from one or more malignancies selected from the group consisting of leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, and one or more immune disorders comprising the steps of:

identifying an individual in need of treatment against the one or more malignancies; and

administering an alkaline diet by itself or as a supplement along with a regular diet, wherein the alkaline diet comprises:

a solution of sodium bicarbonate;

one or more alkaline ash forming foods selected from the group consisting of alfalfa sprouts, artichokes, broccoli, cantaloupe, celeriac, cranberries, dates, flaxseed, huckleberries, lemons, almonds, apples (apple cider) apricots, bananas, beets, blackberries, blueberries, brussel sprouts, burdock cabbage, carob carrots, cauliflower, celery, chard, cherries, chives, coconut, cucumbers, currants, dandelion greens, dill, dock, endive, figs (dried), garlic, grapefruit, green beans, guava, irish moss, kelp, kohlrabi leeks, lettuce, lima beans, limes, loganberries, loquats, molasses, nectarines, oranges, pears, radishes, rutabagas, squash, vegetable oils, mango, melons, millet mint, mulberries, muskmelon, mustard greens, okra, olives, olive oil, onions, papaya, parsley, parsnips, peaches, persimmons, pineapple, plums, pumpkin, raisins, raspberries, rhubarb, romaine, sea grass, sorrell, soybeans, spinach, strawberries, swisschard, tangerines, turnips, water chestnuts, watercress, and watermelon; and

one or more optional flavoring agents, coloring agents, sweeteners, and other organoleptic compounds.


  1. The method of claim 14, wherein the patient is required to have a normal to above normal fluid intake, wherein the fluids comprise water, fruit juices, nutritional drinks, milk and combinations thereof.

  2. An injectable solution of sodium bicarbonate for a treatment of one or more malignancies or for maintaining an alkaline milieu in a patient undergoing an alkaline diet treatment for the one or more malignancies comprising:

a specified quantity of sodium bicarbonate dissolved in deionized water to give a final concentration of 5%; and

one or more pharmaceutical preservatives.



  1. The solution of claim 16, wherein the injectable solution is sterile.

  2. The solution of claim 16, wherein the one or more pharmaceutical preservatives are selected from the group consisting of parabens, benzoic acid and their salts, mercurials, quarternary ammonium salts, benzyl alcohol and other related alcohols, and phenols.

  3. The solution of claim 16, wherein the alkaline diet comprises

a solution of sodium bicarbonate;

one or more alkaline ash forming foods selected from the group consisting of alfalfa sprouts, artichokes, broccoli, cantaloupe, celeriac, cranberries, dates, flaxseed, huckleberries, lemons, almonds, apples (apple cider) apricots, bananas, beets, blackberries, blueberries, brussel sprouts, burdock cabbage, carob carrots, cauliflower, celery, chard, cherries, chives, coconut, cucumbers, currants, dandelion greens, dill, dock, endive, figs (dried), garlic, grapefruit, green beans, guava, irish moss, kelp, kohlrabi leeks, lettuce, lima beans, limes, loganberries, loquats, molasses, nectarines, oranges, pears, radishes, rutabagas, squash, vegetable oils, mango, melons, millet mint, mulberries, muskmelon, mustard greens, okra, olives, olive oil, onions, papaya, parsley, parsnips, peaches, persimmons, pineapple, plums, pumpkin, raisins, raspberries, rhubarb, romaine, sea grass, sorrell, soybeans, spinach, strawberries, swisschard, tangerines, turnips, water chestnuts, watercress, and watermelon; and

one or more optional flavoring agents, coloring agents, sweeteners, and other organoleptic compounds.


  1. The solution of claim 16, wherein the one or more malignancies selected from the group consisting of leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer.

  2. A method of creating, maintaining an alkaline milieu or both for the treatment of one or more malignancies selected from the group consisting of leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, and one or more immune disorders in a patient comprising the steps of:

identifying an individual in need of treatment against the one or more malignancies; and

injecting intravenously a sterile 5% solution of sodium bicarbonate in deionized water along with one or more pharmaceutical preservatives selected from the group consisting of parabens, benzoic acid and their salts, mercurials, quarternary ammonium salts, benzyl alcohol and other related alcohols, and phenols.



  1. The method of claim 21, wherein the solution is injected to create an alkaline milieu in the patient for treatment of the one or more malignancies or to maintain the alkaline milieu created by administration of an alkaline diet in the patient.

  2. The method of claim 22, wherein the alkaline diet comprises:

a solution of sodium bicarbonate;

one or more alkaline ash forming foods selected from the group consisting of alfalfa sprouts, artichokes, broccoli, cantaloupe, celeriac, cranberries, dates, flaxseed, huckleberries, lemons, almonds, apples (apple cider) apricots, bananas, beets, blackberries, blueberries, brussel sprouts, burdock cabbage, carob carrots, cauliflower, celery, chard, cherries, chives, coconut, cucumbers, currants, dandelion greens, dill, dock, endive, figs (dried), garlic, grapefruit, green beans, guava, irish moss, kelp, kohlrabi leeks, lettuce, lima beans, limes, loganberries, loquats, molasses, nectarines, oranges, pears, radishes, rutabagas, squash, vegetable oils, mango, melons, millet mint, mulberries, muskmelon, mustard greens, okra, olives, olive oil, onions, papaya, parsley, parsnips, peaches, persimmons, pineapple, plums, pumpkin, raisins, raspberries, rhubarb, romaine, sea grass, sorrell, soybeans, spinach, strawberries, swisschard, tangerines, turnips, water chestnuts, watercress, and watermelon; and

one or more optional flavoring agents, coloring agents, sweeteners, and other organoleptic compounds.


  1. A pharmaceutical composition for preventing or slowing a growth and a proliferation of one or more cancer cells, induction of an apopotosis of the one or more cancer cells or both in a patient comprising:

a specified quantity of dichloroacetate (DCA) in a solid or liquid dosage form;

a specified quantity of alpha lipoic acid (ALA) in a solid or liquid dosage form; and

one or more optional pharmaceutically acceptable excipients selected from the group consisting of preservatives, bulking agents, anti adherents, lubricants, sweeteners, and other organoleptic agents.


  1. The composition of claim 24, wherein the composition is administered orally or parenterally.

  2. The composition of claim 24, wherein a dosage of the DCA is 10-15 mg/kg of body weight in three divided doses.

  3. The composition of claim 24, wherein the dosage of the ALA is 100 mg/kg of body weight three times a day administered after meals.

  4. The composition of claim 24, wherein the ALA is administered separately by itself or is administered in a composition combined with the DCA.

  5. A method for treating one or more cancers by preventing or slowing a growth and a proliferation of the one or more cancer cells, induction of an apopotosis of the one or more cancer cells or both in a patient comprising the steps of:

identifying an individual in need of treatment against the one or more cancers; and

administering a therapeutically effective amount of a pharmaceutical composition orally or parenterally, wherein the composition comprises:

a specified quantity of dichloroacetate (DCA) in a solid or liquid dosage form;

a specified quantity of alpha lipoic acid (ALA) in a solid or liquid dosage form; and

one or more optional pharmaceutically acceptable excipients selected from the group consisting of preservatives, bulking agents, anti adherents, lubricants, sweeteners, and other organoleptic agents.


  1. The method of claim 29, wherein a dosage of the DCA is 10-15 mg/kg of body weight in three divided doses.

  2. The method of claim 29, wherein the dosage of the ALA is 100 mg/kg of body weight three times a day administered after meals.

  3. The method of claim 29, wherein the ALA is administered separately by itself or is administered in a composition combined with the DCA.

  4. The method of claim 29, wherein the one or more cancers comprise leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer.

  5. A nutrient composition for preventing angiogenesis, a growth, a proliferation or both of one or more cancer cells comprising:

Vitamin C, Vitamin C salts, modifications and derivatives thereof;

one or more amino acids selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, glycine, glutamine, glutamic acid, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, tryptophan, threonine, tyrosine, and valine;

one or more herbal, plant, and animal products comprising tea extracts, catechins, polyphenols, epigaliocatechingallate (EGCG), cardamom, cayenne pepper, ginger, sage, thyme, turmeric, citrus pectin, artemisinin, graviola, carnivora, fish oil (epa + dha), genestein (soybeans), garlic;

one or more mineral supplements; and

one or more optional additives selected from the group consisting of coloring agents, flavoring agents, sweeteners, preservatives, and other organoleptic agents.


  1. A nutrient composition for preventing angiogenesis, a growth, a proliferation or both of one or more cancer cells comprising:


Vitamin C (Ascorbic acid, magnesium

ascorbate, calcium ascorbate, and palmitic ascorbate)



    700 mg

    L-Lysine

    1,000 mg

    L-Proline

    750 mg

    L-Arginine

    500 mg

    N-Acetyl Cysteine

    200 mg

Green tea Extract

Total polyphenols

Catechins

EGCG


Caffeine

    1000 mg

    80%


    60%

    35%


    1%

Minerals

Selenium


Copper

Manganese



    30 mcg


    2 mg

    1 mg

.


  1. The composition of claim 35, wherein the one or more cancers comprise leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer.

  2. The composition of claim 35, wherein the composition is administered once or multiple times in a day.

  3. The composition of claim 35, wherein the composition is administered before or after meals.

  4. The composition of claim 35, wherein the composition is administered by itself or as part of a combination cancer therapy.

  5. The composition of claim 39, wherein the cancer therapy comprises a radiation therapy, a chemotherapy, a surgical procedure, an injection of a polymannan extract, an alkaline diet therapy, administration of dichloroacetate (DCA), and combinations and modifications thereof.

  6. A method for treating one or more cancers by preventing angiogenesis, a growth, a proliferation or both of one or more cancer cells in a patient comprising the steps of:

identifying the patient in need of treatment against the one or more cancers, wherein the one or more cancers comprise leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer; and

administering a nutritional composition comprising:




Vitamin C (Ascorbic acid, magnesium

ascorbate, calcium ascorbate, and palmitic ascorbate)



    700 mg

    L-Lysine

    1,000 mg

    L-Proline

    750 mg

    L-Arginine

    500 mg

    N-Acetyl Cysteine

    200 mg

Green tea Extract

Total polyphenols

Catechins

EGCG


Caffeine

    1000 mg

    80%


    60%

    35%


    1%

Minerals

Selenium


Copper

Manganese



    30 mcg


    2 mg

    1 mg

for the prevention of the angiogenesis, the growth, the proliferation or both of one or more cancer cells in the patient.


  1. The method of claim 41, wherein the composition is administered once or multiple times in a day.

  2. The method of claim 41, wherein the composition is administered before or after meals.

  3. The method of claim 41, wherein the composition is administered by itself or as part of a combination cancer therapy.

  4. The method of claim 44, wherein the cancer therapy comprises a radiation therapy, a chemotherapy, a surgical procedure, an injection of a polymannan extract, an alkaline diet therapy, administration of dichloroacetate (DCA), and combinations and modifications thereof.

    Abstract

    Methods, compositions, and strategies for the treatment of malignant neoplasms are presented herein. The treatment modalities are directed towards exploiting characteristics of cancer cells as well as correcting defective biochemical pathways and systems in the body.




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